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Additionally, the Ser/Thr protein kinase ATM (ataxia telangiectasia mutated) regulates intracellular labile-free iron by phosphorylating NCOA4, which facilitates the interaction between NCOA4 and ferritin, thus maintaining ferritinophagy [30]

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In some embodiments, the mitophagy stimulant prevents poor clearance of mitochondrial debris from the cristae of the mitochondrial matrix