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Each time a cell divides, telomeres shorten slightly

Common Symptoms of Shoulder Arthritis: Persistent, aching shoulder pain, typically deep within the joint Reduced range of motion, making it difficult to lift the arm or perform overhead activities Stiffness and discomfort in the shoulder, particularly in the morning or after periods of rest Grating or grinding sensation (crepitus) when moving the shoulder Weakness in the affected shoulder due to pain and limited mobility Difficulty sleeping on the affected side due to nighttime discomfort Shoulder Impingement Syndrome Shoulder impingement syndrome occurs when the tendons of the rotator cuff become compressed as they pass through the narrow space beneath the acromion (a bony process of the shoulder blade), especially due to repetitive overhead motions, anatomical factors, or muscle imbalances

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The administration of UC-MSCs intraperitoneally (6 h after I/R damage) could lessen oxidative stress and inflammatory responses and reduce the levels of senescence-related proteins by an increased expression of Klotho [167]