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Proc Natl Acad Sci USA 106:12851290 Li Y, Tweedie D, Mattson MP, Holloway HW, Greig NH (2010) Enhancing the GLP-1 receptor signaling pathway leads to proliferation and neuroprotection in human neuroblastoma cells

TRIzol reagent (Invitrogen-Thermo Fisher) and RNeasy Lipid tissue kit (Qiagen, Chatsworth, CA, USA) were used to extract RNA from cultured cells and skin explants, respectively

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Generally, XO only contributes to RS generation to a limited extent in most human tissues (apart from the gastrointestinal tract)