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Several factors have been identified related to the pathogenesis of ALS: OS, mitochondrial dysfunction, neuroinflammation, excitotoxicity due to an increase in the neurotransmitter glutamate, defect in axonal transmission and in the metabolism of RNA, apoptosis, cytoskeletal abnormalities, disruption of membrane trafficking, endoplasmic reticulum stress, protein misfolding and aggregation (Papadimitriou et al., 2010

Therefore, they suggested that antioxidant supplementation should be considered as an adjuvant therapy in DM2 treatment

, 2006), and in cultured rat vascular smooth muscle cells

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