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To achieve this, we investigated if two short hairpin (sh) RNAs (MT3-sh1 and MT3-sh2) that targeted various murine Mt3 mRNA locations could knockdown MT3 expression in BMM via lentiviral transduction

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While APR-246 treatment did cause dose-dependent increase in caspase activity, this appeared to be independent of p53-expression (Fig

Targeted CRISPR/Cas9 delivery against the PLK1 gene significantly inhibited tumor growth and improved survival in mice, showing LHNPs potential as a flexible platform for cancer gene therapy

From the perspective of immunometabolism, this study further underscores the importance of periodontal disease management in maintaining systemic health, offering a theoretical foundation for clinical practice in which controlling local oral inflammation may slow the progression of systemic comorbidities