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V.BolesJ.JamshidiP.et al

MMP2 and MMP9 degrade collagen and other matrix proteins to allow trophoblast penetration, while TIMP1 and TIMP2 limit tissue damage during this process

Additionally, integrating biomarkerguided patient stratification (e.g., based on mitochondrial function or NTFs receptor status) into trial design may help identify subgroups most likely to benefit from axistargeted therapies