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The pharmacology and toxicology of kratom: from traditional herb to drug of abuse

Placentas from HF/HS-fed dams exhibited increased phosphorylation of mTOR targets (rpS6, 4E-BP1) and insulin signaling proteins (IRS-1, Akt), alongside reduced AMPK activation, indicating an overall anabolic placental state linked to fetal overgrowth [49]

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Following cellular entry, GHK-Cu distributes to nuclear and cytoplasmic compartments, where it influences gene transcription and protein synthesis patterns

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