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It downregulates claudin-2 expression via IL-10 receptor alpha (IL-10RA)-dependent pathways, reducing paracellular permeability and maintaining epithelial tension [58]

Structural data indicate that nsp13, the 53 helicase encoded by Coronaviridae , is part of the replicase and might be important for backtracking in the proofreading process during RNA replication 93,94,95