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Raw data for statistical analyses and supplemental data are available at Zenodo (DOI: 10.5281/zenodo.14916225) Ethics statement The animal study was approved by Lower Saxony State Office for Consumer Protection and Food Safety (LAVES, Oldenburg, Germany)

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Kelinda Glesil, Orrington

Psychiatry 23 , 434443 (2018)

Integrative omics analyses reveal that MYC orchestrates ammonium metabolism reprogramming in prostate cancer through direct transcriptional control of GLS, with TCGA-PRAD data confirming co-amplification of MYC and GLS (q 20 mM) impair immune cell function by competitively inhibiting monocarboxylate transporters (MCTs), MCT1 in T cells and MCT4 in NK cells, leading to metabolic paralysis or apoptosis (180) ( Figure 4 )