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By monitoring for the appearance of the ~9 kDa C3a fragment, no cleavage products could be detected, suggesting that Chi homologs did not exert C3b/C3 cleavage activity under the tested conditions

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In addition, we found a strong relationship between endoplasmic reticulum (ER) stress and ferroptosis, and we therefore speculated that sustained ER stress might be a prerequisite for ferroptosis in JEV and HSV-induced diseases