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For example, recent studies have shown that perturbation of COQ2, a key enzyme responsible for coupling the isoprenoid tail to the quinone head group, increases ferroptosis sensitivity, and thus targeting COQ2 enhances ferroptotic vulnerability in multiple myeloma cells 35

For the specific role and pathogenic mechanisms relating CP, HMGB1 and TF to PD, further exploration and verification are still required

this process is impaired in diabetes, contributing to diabetic complications (Yapislar 2012)

F.et al (2025a)

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