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Populations to avoid: Pregnant and breastfeeding individuals, individuals with active neuroendocrine conditions, and those on ACTH-axis medications should not use DSIP without specialist guidance

These cardiovascular effects suggest potential applications in ischemic heart disease, peripheral vascular disease, and vascular injury, though clinical translation requires confirmation of effects in human subjects

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What actually preserves muscle during weight loss The interventions with the strongest evidence for preserving muscle during rapid weight loss are, in order of evidence strength, resistance training, adequate protein intake (1.0-1.6 grams per kilogram of body weight daily), and possibly creatine supplementation

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