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However, several limitations must be acknowledged

Largest effects were observed in monotherapy vs placebo/no treatment , while head-to-head comparisons did not demonstrate superiority of ALC over antidepressant drugs

Sugimoto M, Uchida I, Mashimo T, et al

Vaz FM., et al

the inventors herein have attempted the inverse conversion reaction of 4-hydroxy-3-activated hydroxybutyric acid of formula 3, so obtained via the ring-opening reaction, by epoxidation in the presence of a base