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Obesity-induced suppression of sirtuin activity contributes to oxidative stress, impaired mitochondrial integrity, and potentially transgenerational metabolic dysfunction [54]

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Dosing should be determined by the prescribing physician based on the severity of joint involvement, body weight, and other individual factors

Gastrointestinal adverse events, primarily nausea, vomiting, diarrhea, and constipation, are the predominant side effects, occurring most frequently during dose escalation and generally diminishing with continued treatment