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The (i) initiation stage of tumorigenesis is characterized by increased production of peroxinitrite (ONOO ), superoxide (O 2 ) and hydroxyl ( OH) radicals and hydrogen peroxide (H 2 O 2 ) to accomplish the genetic alterations necessary for independent cellular proliferation

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As per the latest diagnostic criteria, MetS necessitates the presence of any three out of the following five conditions: elevated fasting glucose or type 2 diabetes (T2D), hypertriglyceridemia, lowered high-density lipoprotein (HDL) cholesterol levels, central obesity, or hypertension (Alberti et al., 2009)

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223 It has been reported that high-intensity exercise in hypoxia is more effective to improve vascular function through enhanced NO bioavailability