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ABCB7 is usually characterized as a transporter that exports an unknown product of the iron-sulfur (Fe-S) cluster assembly from the mitochondrial matrix to the cytosol

In conditions of hypermetabolism as it was extensively described in ALS, the mitochondrial respiratory chain require the sustained fueling of energy substrates to maintain a minimal electric membrane potential () to avoid both a REDOX crisis and activation of apoptosis 19

Persson et al

Involvement of reactive oxygen species in toll-like receptor 4-dependent activation of NF-kappa B

151 This suggests that providing iron interventions without first treating the infection will not address anaemia and routine iron supplementation may be potentially harmful in malaria-endemic settings