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10.1016/S2222-1808(14)60509-0 48 OwoadeA

Researchers who assume short half life equals short effect duration are applying the wrong mental model

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The composition of the ECM is different in Acomys wounds and molecules like collagen triple helix repeat containing-1 (CTHRC-1), tenascin-C, fibronectin 1, laminin 1, and aggrecan are upregulated and correlated to a regeneration-inducing environment, although no mechanistic details have been attributed to these components individually 63