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Nevertheless, there are studies providing evidence for an influence of circulating UA on the pathology and behaviour of animal models of PD independent of any humanising effects on uricase activity

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Jun 2013;20(6):650-653

[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Chiang P.K., Gordon R.K., Tal J., Zeng G.C., Doctor B.P., Pardhasaradhi K., McCann P.P

In one embodiment, disulfiram pharmaceutical formulations may be absorbed in the lower ileum/ upper colon to prevent/slow first pass hepatic metabolism