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Basic aspects of the biochemical reactivity of 4-hydroxynonenal

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However, because the multistep chemical reaction of protein nitration by peroxynitrite requires the involvement of a metal ion such as ferrous iron [79], the role of iron in APAP hepatotoxicity is independent of the Fenton reaction under normal conditions [80]

Methods: A murine hepatocyte cell line (MMH) was silenced using lentiviral vectors encoding shRNA for the ERK5 gene