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22 Conditions such as aging, hypertension, ischemic heart disease, diabetes, and chronic lung disease are associated with decreased baseline GSH levels, while smoking, obesity, alcoholism, renal failure, cancers, and other chronic diseases are linked to disruptions in GSH homeostasis, impairing glutathione functionality

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doi:10.1016/j.brainres.2010.11.078

469 The mitochondrial protein sideroflexin 1 (SFXN1) is responsible for importing iron from the cytoplasm to the mitochondria, and SFXN1 deficiency leads to mitochondrial respiratory chain damage, affecting the biogenesis and assembly of complex III

It participates in the regulation of fatty acid metabolism, bile acid synthesis and energy metabolism, helps maintain the balance of fat and sugar, and thus has a preventive and therapeutic effect on metabolic diseases such as metabolic syndrome and diabetes