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Although animals treated with G28UCM experienced tumor development, histological analysis showed that these tumors did not acquire the invasive, malignant phenotype, and growth was limited to in situ ductal carcinoma

This discrepancy may arise from differences in experimental models and detection methods

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Interestingly, we also show that kynurenine, a metabolite derived from tryptophan following inflammatory activation of IDO1 [46,47,48], is elevated in TTR-V30M patients but not in age-matched healthy controls

The UPS removes damaged proteins