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in diet-induced obese mice, 5-Amino-1-MQ significantly reduces total body weight, fat mass, and adipocyte size, while improving insulin sensitivity and glucose tolerance 2,3

Reactions were performed with 0.5 M catechol substrate COMT-S01, 1 M radiolabelled S-adenosyl-L-[methyl-3H] methionine (SAM) co-substrate, and recombinant human COMT enzyme

Geoffrey Littlejohn, adjunct clinical professor at Monash University, said the concept needed clarification in a well-conducted double-blind placebo-controlled study

But over 12 weeks of consistent use with proper diet and training, the fat loss is significant and sustainable