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-Tocopherol was also linked to lower NFT accumulation in brain regions affected in early Braak stages, such as the hippocampus, amygdala, and entorhinal cortex but not in the later-affected brain regions [12] In APOE4 carriers (i.e., individuals with at least one copy of the 4 allele of the apolipoprotein E (APOE) gene, a well-established genetic risk factor for late-onset AD), higher dietary intake of -tocopherol was significantly associated with a slower rate of cognitive decline [46]

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DOI: 10.1073/pnas.1306182110 Ding, N., Yu, R.T., Subramaniam, N., Sherman, M.H., Wilson, C., Rao, R., Leblanc, M., Coulter, S., He, M., Scott, C., Lau, S.L., Atkins, A.R., Barish, G.D., Gunton, J.E., Liddle, C., Downes, M., Evans, R.M

For the intracellular metabolomic analysis, cells were quickly washed for three times with PBS to remove contaminations from the media