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This promotes an imbalance in pro-inflammatory T helper 1 cell (Th1)/anti-inflammatory T helper 2 cell (Th2) cytokine profile making a more pro-inflammatory environment in ADHD [60, 102], which can be related to a defective regulatory T cell (T reg ) regulation

154,155 Considering the positive roles of IL-1 in activating initiative and sustained inflammation, 156 it was postulated that NLRP3-IL-1 signaling might be involved in COVID-CS