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Therefore, a stoma, especially an ileostomy, can shorten the distance from the small intestine to the stoma, which may explain why a significant difference was observed for ileostomy in the analysis

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To counter this constant evolution, seasonal vaccines are redesigned annually on predictions of what will be the dominant circulating variants in the upcoming flu season. Predictions must be made significantly ahead of time owing to the time needed to manufacture sufficient doses of vaccine, which can lead to mismatches between vaccine and circulating strains that almost universally lead to limited efficacy

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