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[20] demonstrated that synaptic activity, mediated via NMDA receptors, boosts the synthesis and utilization of glutathione, thereby adjusting antioxidant capacity to meet the elevated needs of active neurons

However, as CD4/CD8 DN differentiation continues into stages that engage signaling through the pre-T cell receptor (TCR) complex, thymocytes begin to upregulate mitochondrial metabolism with an increasing reliance upon OXPHOS

However, despite these promising findings, definitive clinical evidence remains limited

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However, it is important to point out that integration of basic or animal experiments with epidemiological studies is difficult and should be done with extreme caution