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Each patient undergoes a thorough consultation and assessment to determine the most appropriate therapy

2 Methods 2.1 Human subjects and sample collection We recruited 60 healthy participants belonging to 24 families from Valencia (Spain), including three age groups: adults (W = woman

through the non-oxidative phase, the synthesis of nucleotides will be supported by the provision of ribose-5-phosphate (to which external ribose can also contribute, if ribokinase is present)

Estrogen mutagenicity has also been demonstrated in transfected Big Blue rat2 embyronic cells 26 and Big Blue rats treated with 4-OHE 2 18

*Correspondence: Igor Allaman, EPFL, SV/ Brain Mind Institute/LNDC, AAB 117, Station 19, CH-1015 Lausanne, Switzerland e-mail: [email protected] This article was submitted to Neuroenergetics, Nutrition and Brain Health, a section of the journal Frontiers in Neuroscience