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Tolerogenic dendritic cells modified by tacrolimus suppress CD4 + T-cell proliferation and inhibit collagen-induced arthritis in mice

These may directly affect the healing repair of connective tissues [18,19,20,21,22], presenting NO-system directly related to skeletal muscle and tendon and muscle and tendon injuries, and considering the essential role of NO in healing [39,77] as an ordered multistage process involving inflammation and oxidative stress [78]

Enzymatic or microbial stability: Biopolymer-based carriers such as resistant starch (RS), inulin-type fructans and pectin-based matrices can resist immediate digestion by human amylases and proteases, which is useful for protecting ingredients until they reach the colon

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