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Description

The Serum GC-MS and isotopically quantified serum metabolites (UPLCMS/MS) that have been used in this study are deposited in MassIVE with accession numbers MSV000088042 [ and MSV000088043 [ respectively

Nature 591, 639644

Plasmids Individual gRNAs were cloned into lentiCRISPR v2 (Addgene 52961) or lentiGuide-Puro (Addgene 52963) and cDNAs were cloned in pLenti (Addgene #22255), pMSCV (Clontech), pAAV TBG (Adddgene #105535), or pcDNA4TO (Addgene #60914)