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Neurotrophin gene therapy to promote survival of spiral ganglion neurons after deafness

If oral and intramuscular injections have been proposed historically, alternative treatment routes have been recently proposed with sublingual, intranasal and subcutaneous administrations, which are more patient-friendly than painful intramuscular injections

This is accomplished by decreasing the expression of the mutant p53 protein while increasing the expression of the pro-apoptotic Bax protein in breast cancer cells, thereby offering long-term protection to bodily tissues (Obrador et al., 2023)