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Damaged cytosine products resulting from inflammation, particularly halogenated cytosine residues, are likely to facilitate binding with methyl-binding proteins and enzymatic methylation (101)

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In vitro assays were performed using NUNC 96-well plates (VWR International GMBH, Darmstadt, Germany) and a CLARIOstar plate reader (BMG Labtech, Ortenberg, Germany)

Dark spots and uneven skin tone may also become more noticeable because of sunlight, pollution, or previous acne and irritation