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S1P is a bioactive sphingolipid molecule that regulates various cellular functions, including cell survival, differentiation, migration, proliferation, and immune responses, through its binding to five G protein-coupled receptors (S1PR1 to S1PR5) [69]

It controls circadian rhythms, body temperature, reproduction, immune and cardiovascular systems, energy, and bone metabolism

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Here, the inhibition of wounding-induced ROS accumulation significantly inhibited healing in planarian worms by preventing F-actin reorganisation and epithelial cell rearrangements mediated through c-JUN activation at the wound site 122

L., & Magrina, J