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Nicotinamide N-methyltransferase (NNMT) is a cytoplasmic enzyme that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM, the universal methyl donor) to nicotinamide (the NAD + salvage precursor), producing 1-methylnicotinamide and S-adenosyl-L-homocysteine

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The liver X receptor (LXR) and hepatic lipogenesis

In animal models, subjects treated with SLU-PP-332 were able to run 70% longer and 45% further on treadmill tests compared to controls, despite no increase in actual physical activity

Its primary mechanism is believed to pivot around enhancing lipolysis, the breakdown of fat, and suppressing lipogenesis, the process of fat accumulation [More et al., 2014]