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2022 Mar;39(3):142-146

No significant effect of saffron on the amount of PAB was observed

This is a different approach and the early outcomes being studied are strong enough to make experts curious about whether the triple mechanism can translate into meaningful real-world benefits once larger trials confirm safety and long-term results

On the cardiovascular system, melatonin regulates blood pressure circadian rhythms, exhibits an antagonistic action to angiotensin II (Ag II) [194, 195], and diminishes the flactuation of cerebral blood flow [196]