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Free Radic Biol Med 51: 1087-1105, 2011

The biology does not work that way at any dose we would consider clinically appropriate

Hypoxia increases the deoxycytidine triphosphate (dCTP) level through the pentose phosphate pathway (PPP) via glucose metabolism and results in resistance to gemcitabine, a dCTP analog 87

Breaking plateaus often requires addressing factors beyond peptide dosing