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4-octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to promote cuproptosis in colorectal cancer

Skogs M, Stadler C, Schutten R, et al

Exposure is not limited to inhalation

Determination of the in vivo redox status of cysteine, cysteinylglycine, homocysteine, and glutathione in human plasma

Our results show that glucose deprivation-induced cell death is driven not by lack of glucose, but rather by NADPH depletion following L-cystine import and reduction to L-cysteine