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References: Drugs for treating alcohol dependence -BMJ 2016

Lin J, Jia S, Cao F, Huang J, Chen J, Wang J, Liu P, Zeng H, Zhang X, Cui W

Temporal and spatial control: enables controlled drug release in time and space, improving treatment efficacy and safety

Most studies identify a miRNA or protein switch (miR-138-5p, miR-21a-5p, miR-99b-3p, miR-421-3p, 14-3-3, resveratrol) that ultimately suppresses the PI3K/AKT/mTOR axis or liberates core autophagy genes (ATG7, Beclin-1)