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The targets of differentially expressed CircRNAs were predominantly connected to apoptosis, Phosphatidylinositol3-kinase-RAC-beta serine/threonine-protein kinase(PI3K-AKT), and Cellular tumor antigen p53 signaling pathways by sequencing the CGCs of women with EMS and women without EMS (52)

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J Pharmacol Toxicol 7(1):3845 Nutalapati C, Chiranjeevi UK, Kishan PV, Kiran KK, Pingali U (2016) A randomized, double-blind, placebo-controlled, parallel group clinical study to evaluate the analgesic effect of aqueous extract of Terminalia chebula , a proprietary chromium complex, and their combination in subjects with joint discomfort

Multiple studies have shown that luteolin induces apoptosis (cell death) in cancer cells in vitro