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GPX4 impairment through the inhibition of system xc have been discovered and classified as class 1 inducers (Table 4)

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Brque C, Surai P, Brillard JP (2003) Roles of antioxidants on prolonged storage of avian spermatozoa in vivo and in vitro

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It is produced from the precursor thyroglobulin (this is not the same as thyroxine-binding globulin [TBG]), which is cleaved by enzymes to produce active T 4