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Nuclear gene therapy represents an alternative strategy, as numerous mitochondrial proteins are encoded by nuclear genes

Additional factors have been implicated in the induction of ferroptosis 13 , including the engagement of mitochondrial metabolism and the tricarboxylic acid (TCA) cycle 14,15

doi: 10.1016/s0014-5793(97)00380-3

10.1038/s41419-018-0865-6 18 FormanH

Numerous studies have indicated that in scenarios of iron overload, there is an increase in mitochondrial stress, which results in mitochondrial fragmentation and a disruption of the fission and fusion [68, 130]