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The Pigment Switch By inhibiting this enzyme, cells begin to produce less dark pigment and lighter pheomelanin

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Keywords Methaqualone (Quaalude) Toxicology Source: a non-barbiturate sedative-hypnotic Mechanism of Action: a sedative hypnotic that stimulates the actions of GABA on GABA A receptors by binding to a transmembrane site distinctly different from the binding sites for benzodiazepines and barbiturates (Hammer et al, 2015) Symptoms: resembles barbiturate poisoning ataxia : produces pronounced motor problems & is known as wallbanger because of this phenomenon Can lead to severe muscular hypertonicity and seizures Treatment: no diuresis diazepam for severe muscular tone or seizures strongly consider phenytoin as an anticonvulsant because barbiturates potentiate the effect of methaqualone Notes: Methaqualone (quaaludes) were popular recreational drugs in the 1960's and 70's, especially in disco clubs