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The necrosis of SPG is predominantly acral and bilateral at least two locations including the toes, fingers, scrotum, and earlobes, without major vascular occlusive disease, while the term purpura fulminans (PF) refers to the occurrence the non-acral necrosis ( Sepsis is the underlying disorders of SPG, with some studies suggesting an estimated frequency of 2%6% in sepsis ( The etiological factors leading to SPG include septic and non-septic factors, as shown in Table 2

P2X7R increases inflammatory progression and brain injury in ICH mice, potentially increasing IL-1/IL-18 release and neutrophil infiltration through the NLRP3 inflammasome

Researchers have found that more than half of patients with hypothyroidism had muscle complaints, with 54 percent experiencing muscle weakness and 42 percent experiencing cramps

10.1002/glia.10161 37 HeQ.SongN.JiaF.XuH.YuX.XieJ.et al (2013)

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