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Description

In the description of each linear mixed effect model below we provide the characteristics of the factors tested

Methods: We analyzed the whole-genome sequencing (WGS) data of a total of 768 samples including 529 multi-regional WGS data from 26 patients with or without HCC (cohort 1:in house and public data) and 239 bulk WGS data from 228 patients with HCC (cohort 2: ICGC database)

Cell 165 , 14401453 (2016)

In addition, traditional approaches are constrained by significant time and cost limitations, hindering their capacity to meet the demands of modern drug discovery