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comorbidities and pharmacotherapy exposure confound HDAC6 expression estimates (55)

Of note, concentrations of lactate above 13.5 mM, 5-oxoproline (above 68.3 uM), glutamine (8.6 uM), GSH (1.0 mM) and citrulline (1.1 uM) had areas under the curve (AUC) 0.7

Cell debris was precipitated by adding 150 L of Tail Salts Buffer (4.31 M NaCl, 0.63 M HCl, 10 mM TrisHCl, pH7.4) then samples were centrifuged at ~ 21,000 g for 15 min at 4 C

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the method comprises administering to a human in need of such treatment a pharmaceutical composition comprising a cyclobenzaprine analog disclosed herein in a therapeutically effective amount and a therapeutically acceptable carrier