Examples include: peptide therapy (at high doses or long-term use) TB-500 (Thymosin Beta-4) VEGF-mimetic peptides Tesamorelin/peptide therapy (via IGF-1 pathways) Potential risks of prolonged use: Scar tissue overdevelopment Feeding abnormal or cancerous cell growth Disrupting blood flow in sensitive tissues (eyes, kidneys) Thats why we recommend cycles like: TB-500 : 610 weeks on, 4+ weeks off peptide therapy injections : short-term, with oral BPC for maintenance Tesamorelin/peptide therapy : rotated or paused to avoid overexposure Other Peptides That Benefit From Cycling Even non-angiogenic peptides benefit from breaks: Thymosin Alpha-1 : 5-week cycles, 23x per year GHK-Cu : 78 week cycles, followed by rest Semax & Dihexa : pulsed use to maintain brain sensitivity 5-Amino-1MQ : cycled after 23 rounds for metabolic reset Each protocol is tailored to half-life, tissue targets, and sensitivity feedback
Eventually, free radicals in tissues and cells will increase, making cells more susceptible to damage
doi: 10.1002/bjs.1800800632
Mysore doesn't recommend MSM routinely to patients, she says if a patient was coming to her with joint pain, she would recommend rest, anti-inflammatories (Advil or Tylenol, for instance), physical therapy, acupuncture, and other low-impact exercise like swimming before recommending MSM
Pan S, Wei H, Yuan S, Kong Y, Yang H, Zhang Y, Cui X, Chen W, Liu J, Zhang Y (2022) Probiotic Pediococcus pentosaceus ameliorates MPTP-induced oxidative stress via regulating the gut microbiota-gut-brain axis
