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Important Note: Its crucial to remember that these experiments were done in vitro in lab dishes with cultured cells

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Strategies include testing isolated constituents versus the whole extract, using knockdown of specific pathways in cells or gene knockout models in animals to see if the effect persists, and applying pharmacological inhibitors to block suspected mechanisms

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This is why many people look toward supplementation to bridge the gap

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[,] During the oxidative reaction, tocopherol and tocotrienol donate electrons to the radicals forming vitamin-radical complexes

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Gilliham M, Tyerman SD (2016) Linking metabolism to membrane signaling: the GABAmalate connection

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