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L-cystine, the disulfide form of L-cysteine, is transported across the CSFbrain barrier via the Na + - independent L-cystine/L-glutamate exchanger system (Shih et al., 2006)

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The studies in yeast provided the first direct evidence for ATP-dependent, low-affinity transport of GSH in any cell type (Rebbeor et al., 1998a), and demonstrated that this ATP-dependent GSH transport in yeast is mediated by Ycf1p, the yeast orthologue of mammalian MRP1 and MRP2 (Rebbeor et al., 1998b)

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Dose selections for SeNPs were conducted according to previous publications with minor modifications (26, 27)