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Comprehensive discussion of these factors, their hypothesized cellular sources, and their paracrine vs

Some evidence suggests that in AD, dysregulation of tight junction proteins, increased matrix metalloproteinase signaling, and degeneration and loss of pericytes may all contribute to BBB leakage, leading to the accumulation of numerous blood-derived neurotoxic proteins in the brain, causing neuroinflammation and oxidative stress

10.1152/ajpregu.00247.2017 117

There should be medical director oversight, clear emergency protocols, and transparent policies about what's in your drip and what risks you might face