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Riboflavin (Vitamin B2) forms flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), both acting as electron carriers in redox reactions within the mitochondrial electron transport chain

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There are two distinct COX isoforms

A monothiol mechanism was also reported for the in vitro reduction of mammalian RNR 46 and can be also employed, although with a decreased activity, by a Grx-RNR fusion protein from Facklamia ignava 47

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