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6.2.3.2 Myelin vacuolization and demyelination NO-induced Vit B12 inactivation results in MMA accumulation (Weil et al., 2016)

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Usually, an enzyme breaks down trimethylamine as part of the digestion process

Furthermore, as tyrosine is necessary for protein synthesis, the amount of gamma-glutamyl tyrosine may indicate the direction of an animals protein metabolism (30)

Therefore, this review elucidates the etiology, inducements, pathogenesis and treatment modalities of migraine, the clinical evidence that migraine is associated with oxidative stress and neurogenic inflammation, as well as the experimental evidence of antioxidant and anti-inflammatory effects of topiramate, which is of great significance for further research and exploration of the possible mechanisms of topiramate in the treatment of migraine by modulating oxidative stress and neurogenic inflammatory pathways